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Related Experiment Videos

Prostate plasma membrane receptor: a hypothesis.

W E Farnsworth1

  • 1Department of Biochemistry, Chicago College of Osteopathic Medicine, Downers Grove.

The Prostate
|January 1, 1991
PubMed
Summary
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Prostate function, including cell growth and citrate secretion, is regulated by the hormone-sensitive Na, K-ATPase. This enzyme

Area of Science:

  • Prostate biochemistry and physiology
  • Endocrinology
  • Membrane transport

Background:

  • Prostate function is influenced by androgen control.
  • Existing knowledge of prostate biochemistry and physiology has evolved over 50 years.
  • The role of specific membrane transport mechanisms in prostate function requires further elucidation.

Purpose of the Study:

  • To test the hypothesis that Na, K-ATPase modulates prostate cell proliferation, biosynthesis, metabolism, and secretion.
  • To investigate the coupling of citrate production and secretion to prostate cell number and function.
  • To understand androgen binding and its interaction with Na, K-ATPase in the prostate.

Main Methods:

  • Synthesis of technologies from endocrinology, intermediary metabolism, and membrane transport.

Related Experiment Videos

  • Preliminary experimental investigations into prostate cell mechanisms.
  • Analysis of hormone-sensitive Na, K-ATPase activity.

    • Main Results:

    • The Na, K-ATPase appears to modulate key prostate cellular processes.
    • Extraordinary citrate production and secretion may be linked to sustaining prostate cell function.
    • Androgen interaction with Na, K-ATPase is under investigation.

    Conclusions:

    • The hormone-sensitive Na, K-ATPase is a key regulator of prostate biochemistry and physiology.
    • Citrate metabolism and secretion are potentially coupled to prostate cell homeostasis.
    • Differential cell properties and growth factor environments contribute to prostate function.