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[Fatigability and weakness from a neurological viewpoint].

C Meier1

  • 1St. Gallische Höhenklinik Walenstadtberg.

Therapeutische Umschau. Revue Therapeutique
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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Fatigue is a common symptom in neurological disorders, often presenting as fluctuating weakness. Diagnostic evidence for fatigue is limited to peripheral nervous system conditions, not central nervous system disorders.

Area of Science:

  • Neurology
  • Neuroscience

Context:

  • Fatigue is a prevalent yet poorly defined symptom across central and peripheral nervous system disorders.
  • It manifests as fluctuating incapacity or weakness, frequently without apparent paresis.

Purpose:

  • To clarify the nature of fatigue in neurological conditions.
  • To differentiate the diagnostic evidence of fatigue between central nervous system (CNS) and peripheral nervous system (PNS) disorders.

Summary:

  • Fatigue is characterized by fluctuating weakness, often without overt paresis.
  • Experimental or diagnostic evidence for fatigue is established in peripheral motor neuron, neuromuscular junction, and muscle fiber disorders.
  • Currently, no such diagnostic evidence exists for fatigue in central nervous system disorders.

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Impact:

  • Highlights the diagnostic challenges associated with fatigue in neurological diseases.
  • Warns against potential misdiagnosis of fatigue as malingering due to its fluctuating nature.
  • Emphasizes the need for further research into the mechanisms and diagnosis of fatigue in CNS disorders.