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Updated: Aug 9, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
CAGE displays oncogenic potential and induces cytolytic T lymphocyte activity
Eunsook Shim1, Hyeeun Shim, Jinhee Bae
1School of Biological Sciences, College of Natural Sciences, Kangwon National University, 200-701, Chunchon, Republic of Korea.
Abstract:
The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine.
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