Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neovalve construction in postthrombotic syndrome.

Oscar Maleti1, Marzia Lugli

  • 1Department of Cardiovascular Surgery, Hesperia Hospital, Modena, Italy. chir.vasc@hesperia.it

Journal of Vascular Surgery
|April 18, 2006
PubMed
Summary

This study shows neovalve construction effectively treats postthrombotic syndrome, healing ulcers and restoring venous competence. Further research is needed to confirm long-term efficacy of this novel surgical technique.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus statement on mesotherapy for clinical and regulatory practice.

Rheumatology international·2026
Same author

International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy: A Multidisciplinary Statement.

Journal of clinical medicine·2025
Same author

2025 ESVM Guidelines on interventional treatment of venous thromboembolism.

VASA. Zeitschrift fur Gefasskrankheiten·2025
Same author

A venous hemodynamic model and measurement of venous reflux in the lower limb during walking-Proof of concept.

Journal of vascular surgery. Venous and lymphatic disorders·2025
Same author

Michel Perrin Memorial.

Phlebology·2023
Same author

Systematic review and meta-analysis of deep venous reflux correction in chronic venous insufficiency.

Journal of vascular surgery. Venous and lymphatic disorders·2023

Area of Science:

  • Vascular Surgery
  • Venous Thromboembolism
  • Surgical Innovation

Background:

  • Postthrombotic syndrome (PTS) causes severe chronic venous insufficiency, often presenting as nonhealing or recurrent ulcers.
  • Current treatments for PTS have limitations, necessitating novel surgical approaches.
  • Femoral venous incompetence is a key factor in severe PTS, leading to significant morbidity.

Purpose of the Study:

  • To evaluate a new neovalve construction technique for treating severe postthrombotic syndrome.
  • To describe the surgical procedure for neovalve creation.
  • To present preliminary outcomes of the first case series using this technique.

Main Methods:

  • Neovalve construction was performed on 18 limbs in 16 patients with severe PTS (CEAP C6) between 2000 and 2004.

Related Experiment Videos

  • Preoperative assessment included duplex scanning, venography, and air plethysmography.
  • Valvular cusps were fashioned from the patient's own venous wall, creating a monocuspid or bicuspid valve.

    • Main Results:

    • Ulcer healing occurred in 89% of limbs within a median of 12 weeks, with no recurrences.
    • Neovalve competence was confirmed in 95% of cases, and treated segments remained patent in 95% at a median follow-up of 22 months.
    • Significant hemodynamic improvement was observed, though early thrombosis occurred in 12% and late occlusion in 6%.

    Conclusions:

    • Neovalve construction demonstrates potential effectiveness in restoring femoral competence in PTS.
    • The preliminary results are encouraging for managing severe PTS.
    • Long-term follow-up and larger patient cohorts are necessary to validate this innovative surgical technique.