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A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Cervicofacial vascular anomalies. II. Vascular malformations
Ravindhra G Elluru1, Richard G Azizkhan
1Division of Pediatric Otolaryngology/Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. ravi.elluru@cchmc.org
Seminars in Pediatric Surgery
|April 18, 2006
Summary
Vascular malformations are congenital vascular anomalies characterized by abnormal channel development, not cellular proliferation. This review covers their presentation, diagnosis, and management, focusing on head and neck cases.
Area of Science:
- Vascular anomalies research
- Pediatric vascular lesions
- Congenital malformations
Background:
- Vascular malformations are congenital, growing with the child, unlike vascular tumors.
- Their molecular origins are unclear, but they stem from abnormal development and morphogenesis.
- Histology shows progressive dilation of abnormal channels, not cellular proliferation.
Purpose of the Study:
- To describe the clinical presentation of vascular malformations.
- To outline diagnostic approaches for vascular malformations.
- To detail management strategies for vascular malformations, emphasizing head and neck cases.
Main Methods:
- Review of clinical presentations.
- Diagnostic criteria analysis.
- Management strategies evaluation.
Main Results:
- Vascular malformations are classified by predominant channel type: capillary, venous, lymphatic, arterial, or combined.
- Arterial malformations are fast-flow; others are slow-flow.
- Morbidity varies significantly across types and within subgroups.
Conclusions:
- Vascular malformations require accurate diagnosis and tailored management.
- Understanding classification aids in predicting flow characteristics and morbidity.
- This review highlights key aspects of vascular malformation care, particularly in the head and neck region.
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