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In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb
Yaya Rukayadi1, Dongeun Yong, Jae-Kwan Hwang
1Department of Biotechnology & Bioproducts Research Center (BRC), Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, Korea.
Objectives:
Xanthorrhizol, isolated from the methanol extract of Curcuma xanthorrhiza Roxb., was investigated for its anticandidal activity using six Candida species.
Methods:
The in vitro susceptibility tests for xanthorrhizol were carried out in terms of MIC and minimal fungicidal concentration (MFC) using the NCCLS M27-A2 broth microdilution method. Time-kill curves were determined to assess the correlation between MIC and fungicidal activity of xanthorrhizol at concentrations ranging from 0 MIC to 4x MIC.
Results:
All Candida species showed susceptibility to xanthorrhizol in the MIC range 1.0-15.0 mg/L for Candida albicans, 1.0-10 mg/L for Candida glabrata, 2.0-8.0 mg/L for Candida guilliermondii, 2.5-7.5 mg/L for Candida krusei, 2.5-25 mg/L for Candida parapsilosis and 2.0-8.0 mg/L for Candida tropicalis. Time-kill curves demonstrated that xanthorrhizol was able to kill the Candida strains with MFCs of 20 mg/mL, 15 mg/mL, 12.5 mg/mL, 10 mg/L, 30 mg/mL and 10 mg/L for C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis and C. tropicalis, respectively.
Conclusions:
The potent anticandidal activity of xanthorrhizol may support the use of C. xanthorriza for the treatment of candidiasis.
