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[Dietary fiber. Effect on colon carcinogenesis].
1Zentralinstitut für Ernährung in Potsdam-Rehbrücke, Bundesrepublik, Deutschland.
Die Nahrung
|January 1, 1991
Summary
Bile acids promote colon cancer by altering pH and metabolism. Specific plant-based foods, like bran, may delay cancer promotion, but dietary fiber alone does not offer protection.
Area of Science:
- Gastroenterology
- Oncology
- Nutritional Science
Background:
- Colon carcinogenesis is a multi-step process involving initiation and promotion.
- Xenobiotics in human nutrition are typically present at concentrations too low to initiate cancer.
- Bile acids are strongly implicated as promoters of colon carcinogenesis.
Purpose of the Study:
- To investigate the role of bile acids in colon carcinogenesis.
- To explore the mechanisms by which bile acids promote colon cancer.
- To evaluate the protective effects of dietary fiber and specific plant products against colon cancer.
Main Methods:
- Analysis of factors influencing bile acid promotion, including pH and metabolism.
- Investigation of the impact of dietary lipid content on bile acid-related processes.
- Assessment of the effects of dietary fiber and plant products (bran, lupin) on colon tumor development.
Main Results:
- Factors influencing bile acid promotion likely involve decreased pH and altered bile acid metabolism (e.g., 7-alpha-dehydroxylase).
- Dietary lipid content indirectly affects these processes via cholegenesis.
- Dietary fiber did not show a protective effect; only specific plant products like bran and lupin demonstrated a delay in the promotion phase of colon carcinogenesis.
Conclusions:
- Bile acids play a significant promoting role in colon carcinogenesis.
- Dietary interventions targeting bile acid promotion, particularly through specific plant-derived products, may be beneficial.
- The protective effects attributed to dietary fiber may be due to delayed promotion rather than direct prevention.