Related Experiment Videos
Microalbuminuria presents the same vascular risk as overt CVD in type 2 diabetes
José Antonio Gimeno-Orna1, Edmundo Molinero-Herguedas, Raquel Sánchez-Vaño
1Department of Internal Medicine, Alcañiz Hospital, Teruel, Spain. jagimeno@salud.aragon.es
Objectives:
We attempted to assess whether microalbuminuria conferred the same cardiovascular risk as overt CVD in type 2 diabetic patients.
Material And Methods:
A prospective cohort study including 436 type 2 diabetic patients (64.8+/-9.2 years old) without proteinuria, with follow-up until any cardiovascular event occurred, was performed. Patients were classified into four groups: group 0, non baseline CVD and normoalbuminuria; group 1, non baseline CVD and microalbuminuria; group 2, baseline CVD and normoalbuminuria; group 3, baseline CVD and microalbuminuria. Cox's multivariate regression models were used to assess the risk ratio (RR) associated with each variable.
Results:
The median follow-up time was 7.6 years. Incidence rates of cardiovascular events per 1000 patient-years increased from groups 0 to 3 (23.8, 63.4, 74.1, 85.6; p<0.0001). Multivariate RR for incident CVD in groups 1, 2 and 3 in relation to group 0 were 2.8 (95% confidence interval (CI) 1.7-4.6; p<0.0001), 2.7 (95% CI 1.6-4.6; p<0.0001) and 2.9 (95% CI 1.6-5.4; p=0.001), respectively. No significant differences were seen between groups 1 and 2.
Conclusions:
We suggest that patients with microalbuminuria are at very high vascular risk and should share the same objectives of a vascular risk-factor control as patients with overt CVD.
Related Concept Videos
Diabetic Nephropathy
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Diabetic Retinopathy
Diabetes Mellitus: Type 2 and Gestational
Type I Diabetes III: Clinical Manifestations
Type II Diabetes II: Pathophysiology