Related Experiment Video
Updated: Aug 9, 2026

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function
Published on: January 22, 2017
Other causes of ataxia in patients with SCA mutations
Steven B Dawson1, John C Morgan, Kapil D Sethi
1School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.
Abstract:
Autosomal dominant spinocerebellar ataxias (SCAs) are slowly progressive and have a variable clinical presentation. Overlapping clinical features among the SCAs make the clinical diagnosis of these ataxias difficult. Even when genetic testing identifies an SCA mutation, clinicians should be vigilant for other causes of neurological dysfunction in these patients. We report two patients who developed other causes of ataxia in the setting of SCA-3 and SCA-8 mutations, respectively.
Related Concept Videos
Parkinson Disease ll: Pathophysiology
Secondary Spinal Cord Injury llI: Pathophysiology
Alterations in Muscle Tone ll
Mutations
Parkinson Disease l: Introduction
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

