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A new drug-release method using the Staudinger ligation
Michel Azoulay1, Gérald Tuffin, Wafa Sallem
1UMR 176 CNRS/Institut Curie, Centre de Recherche, 26 rue d'Ulm, F-75248 Paris Cedex 05, France.
Bioorganic & Medicinal Chemistry Letters
|April 20, 2006
Abstract:
Many drugs induce severe side-effects caused by their lack of selectivity. One way to overcome this problem is to design a specific system which releases a free drug in a controlled manner. Herein we describe a new way to liberate a drug from a prodrug using the Staudinger ligation as the trigger.

