Related Experiment Video
Updated: Aug 9, 2026
09:58
A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
Relationship among pulmonary function, bronchial hyperresponsiveness, and atopy in children with clinically stable
Eugene Yang1, Woojung Kim, Byoung Chul Kwon
1Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, CPO Box 8044, Seoul, 120-752, South Korea.
Lung
|April 20, 2006
Summary
Children with stable asthma show reduced lung function, particularly those with higher bronchial hyperresponsiveness (BHR). This study highlights BHR as a key factor in pediatric asthma pulmonary obstruction.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Allergy and Immunology
Background:
- Pulmonary function testing is crucial for diagnosing and managing childhood asthma.
- Existing literature lacks clarity on lung function deficits in clinically stable pediatric asthma.
- Assessing lung function and bronchial hyperresponsiveness (BHR) in children is essential.
Purpose of the Study:
- To compare lung function in clinically stable asthmatic children versus non-asthmatic controls.
- To investigate the relationship between pulmonary function, BHR, and other factors like atopy and IgE levels.
- To determine if stable childhood asthma is associated with pulmonary obstruction and its correlation with BHR.
Main Methods:
- Compared lung function (FEV1, FEV1/FVC, FEF25-75, PEF) in 242 stable asthmatic children and 100 controls.
- Measured BHR using methacholine challenge (PC20 for 20% FEV1 fall).
- Analyzed associations with atopy, serum IgE, and total eosinophil count (TEC).
Main Results:
- Asthmatic children exhibited significantly decreased pulmonary function across all measured parameters.
- Pulmonary function was not significantly influenced by atopy, serum IgE, or TEC.
- A strong association was found between pulmonary function parameters and the degree of BHR; children with higher BHR had markedly reduced lung function.
Conclusions:
- Clinically stable children with asthma demonstrate pulmonary obstruction.
- The degree of BHR is a significant factor associated with reduced lung function in these children.
- PC20 showed a direct correlation with pulmonary parameters in asthmatic children, particularly in atopic individuals with higher TEC.
Related Concept Videos
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...