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Updated: Aug 9, 2026
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A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation
Published on: March 13, 2026
[Modifications in the abdominal wall after prostheses implant in guinea pigs. Experimental preliminary study]
1Clinica de Chirurgie Colentina, Spitalul Colentina, Bucureşti. monicananu@home.ro
Chirurgia (Bucharest, Romania : 1990)
|April 21, 2006
Summary
Giant incisional hernia repair requires prostheses. This study found polypropylene meshes superior to polyester (Plastex), recommending polypropylene for abdominal wall repair and avoiding intraperitoneal placement.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Experimental Surgery
Background:
- Giant incisional hernia treatment often necessitates alloplastic prostheses.
- While chemically biocompatible, current prostheses carry risks like infection, obstruction, and fistula.
Purpose of the Study:
- To evaluate prosthesis incorporation into the abdominal wall in Guinea pigs.
- To assess complications associated with different meshes and implantation methods.
- To determine the necessity of biomaterial fixation.
Main Methods:
- Macroscopic and microscopic examination of 59 Guinea pigs.
- Implantation of polypropylene (Marlex) and polyester (Mersilene, Plastex) prostheses.
- Pre-peritoneal and intraperitoneal placement, with and without fixation.
Main Results:
- Plastex mesh showed poor incorporation (7 cases).
- Intraperitoneal placement led to adhesions; obstruction and fistula occurred.
- Polypropylene (Marlex) demonstrated better incorporation than polyester meshes.
Conclusions:
- High-quality prostheses, particularly polypropylene (Marlex), are recommended.
- Avoid Romanian polyester mesh (Plastex) due to biocompatibility issues.
- Intraperitoneal prosthesis implantation is contraindicated; adequate fixation prevents migration.
