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Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular stores
L Missiaen1, F Wuytack, L Raeymaekers
1Laboratory of Molecular Signalling, Department of Zoology, Cambridge, U.K.
Pharmacology & Therapeutics
|January 1, 1991
Summary
This review details cellular calcium (Ca2+) removal systems, including plasma membrane pumps and exchangers, and sarco(endo)plasmic reticulum Ca2+ pumps. It highlights molecular biology advances and regulatory mechanisms.
Area of Science:
- Cellular Biology
- Biochemistry
- Physiology
Background:
- Cytoplasmic calcium homeostasis is crucial for cellular functions.
- Dysregulation of intracellular calcium (Ca2+) contributes to various pathologies.
- Understanding Ca2+ removal mechanisms is key to cellular signaling research.
Purpose of the Study:
- To provide a comprehensive summary of cellular systems responsible for removing calcium (Ca2+) from the cytoplasm.
- To review the regulation and molecular biology of key Ca2+ transport proteins.
- To consolidate current knowledge on Ca2+ efflux and sequestration pathways.
Main Methods:
- Literature review focusing on Ca2+ transport systems.
- Analysis of findings from molecular biology and functional studies.
- Synthesis of information on plasma membrane and organelle Ca2+ handling.
Main Results:
- Detailed examination of the plasma membrane Ca2+ pump and Na(+)-Ca2+ exchanger.
- Discussion of sarco(endo)plasmic reticulum Ca2+ pumps and their isoforms.
- Overview of mitochondrial Ca2+ uptake mechanisms.
Conclusions:
- Multiple, finely-tuned systems regulate cytoplasmic Ca2+ levels.
- Molecular biology has elucidated diverse Ca2+ pump isoforms and their functions.
- Further research into Ca2+ transport is vital for understanding cellular signaling and disease.