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Published on: April 15, 2015
ALDH2 promoter polymorphism has no effect on the risk for alcoholism
Mitsuru Kimura1, Shigeko Kimura, Sachio Matsushita
1National Hospital Organization, Kurihama Alcoholism Center, 5-3-1 Nobi, Yokosuka, Kanagawa 2390841, Japan.
Aim:
To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism.
Methods:
Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed.
Results:
There were no significant differences between the genotype and allele frequencies of the -357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms.
Conclusion:
These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.
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