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Beta receptor derangement in postinfarction left ventricular perianeurysm tissue
J M Levett1, L B McGrath, J M Bianchi
1Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick.
Clinical Cardiology
|November 1, 1991
Summary
Left ventricular aneurysms after infarction show altered adrenergic receptor density. Specifically, beta receptors are up-regulated around the aneurysm, potentially increasing arrhythmia risk.
Area of Science:
- Cardiology
- Molecular Biology
- Pathophysiology
Background:
- Left ventricular aneurysms are a complication of myocardial infarction.
- Adrenergic receptor alterations may play a role in post-infarction cardiac remodeling and arrhythmogenesis.
Observation:
- This study investigated adrenergic receptor density in tissues from patients with left ventricular aneurysms.
- Resected specimens were analyzed for beta, alpha, and muscarinic receptors in border zone, perianeurysm, and infarcted tissues.
Findings:
- Beta receptors showed significant up-regulation in the perianeurysm tissue (p = 0.0003).
- No significant alterations were observed in alpha or muscarinic receptor densities.
Implications:
- Myocardial infarction leading to aneurysm formation alters adrenergic receptor expression.
- Increased beta receptor density may contribute to altered cellular responses and increased susceptibility to arrhythmias in these patients.