Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phase behavior of polyampholytes from charged hard-sphere chain model.

Jianwen Jiang1, Jian Feng, Honglai Liu

  • 1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore. chejj@nus.edu.sg

The Journal of Chemical Physics
|April 22, 2006
PubMed
Summary

A new molecular theory accurately predicts polyampholyte phase behavior. Polyampholyte phase envelopes change with sequence, chain length, and charge distribution, showing distinct scaling relations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compartmentalized co-delivery of CD73 (ecto-5'-nucleotidase) mRNA and rotenone using pH/ROS dual-responsive microgels for neuroinflammation therapy.

International journal of biological macromolecules·2026
Same author

Surface engineering of nano silicon <i>via in situ</i> copolymer grafting for lithium ion batteries.

Nanoscale·2026
Same author

A terahertz graphene-metamaterial sensor for highly sensitive detection of trace pesticide metaldehyde.

PloS one·2025
Same author

Surface Charge Regulation of Nanoplastics in Aquatic Environments.

The journal of physical chemistry. B·2025
Same author

Mesoscopic-scale insights into cellular internalization of deformable polymeric nanoparticles: Structural heterogeneity vs networked elasticity.

Colloids and surfaces. B, Biointerfaces·2025
Same author

Deformation-Induced Enthalpy-Entropy Competition Governs Cellular Penetration of Elastic Polymer Nanoparticles: Molecular Thermodynamic-Dynamic Simulations.

Biomacromolecules·2025

Area of Science:

  • Polymer Physics
  • Thermodynamics
  • Materials Science

Background:

  • Polyampholytes are polymers with both positive and negative charges.
  • Understanding their phase behavior is crucial for designing new materials.
  • Existing theories often struggle to capture complex polyampholyte interactions.

Purpose of the Study:

  • To develop a molecular thermodynamic theory for polyampholytes.
  • To predict the phase behavior of polyampholytes based on sequence and chain length.
  • To investigate the influence of charge distribution on phase transitions.

Main Methods:

  • Developed a molecular thermodynamic theory using a coarse-grained charged hard-sphere chain model.
  • Compared theoretical predictions with simulation results and experimental data.

Related Experiment Videos

  • Analyzed phase envelopes, critical points, and scaling relations.

    • Main Results:

    • The theory accurately predicts polyampholyte phase behavior across various sequences and chain lengths.
    • Less random charge distributions lead to expanded phase envelopes at fixed chain lengths.
    • Increasing chain length expands phase envelopes for diblock and random polyampholytes but shrinks them for zwitterionic ones.
    • Predicted critical temperature, density, and pressure show clear scaling with chain length for all types.

    Conclusions:

    • The developed molecular thermodynamic theory provides a robust framework for understanding polyampholyte phase behavior.
    • Chain length and charge distribution are critical factors governing polyampholyte phase transitions.
    • The findings offer insights into the design and application of polyampholyte-based materials.