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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

[A randomized comparative study of using enoxaparin or UFH adjunctive to percutaneous coronary intervention in

Ji-lin Chen1, Jue Chen, Shu-bin Qiao

  • 1Department of Cardiology, Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China. jilin.chen@263.net

Zhonghua Xin Xue Guan Bing Za Zhi
|April 22, 2006
PubMed

Insights

Enoxaparin is as effective and safe as unfractionated heparin (UF) for patients with coronary heart disease undergoing coronary angiography. Enoxaparin allows immediate sheath removal post-procedure, improving patient outcomes.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Coronary heart disease (CHD) management often involves procedures like coronary angiography (CAG) and percutaneous coronary intervention (PCI).
  • Unfractionated heparin (UF) is a standard anticoagulant, but alternatives are explored for improved safety and efficacy.

Purpose of the Study:

  • To compare the efficacy and safety of enoxaparin versus UF in patients with CHD undergoing CAG with or without PCI.
  • To assess the feasibility of immediate sheath removal after PCI when using enoxaparin.

Main Methods:

  • A randomized trial involving 966 patients with CHD from Oct 2003 to Feb 2005.
  • Patients received either enoxaparin (subcutaneous) or UF (intravenous) prior to CAG.
  • PCI was performed in 455 patients, with specific dosing and sheath removal protocols for each group.

Main Results:

  • The incidence of major adverse cardiac events was low in both groups (0.44% for enoxaparin, 0% for UF).
  • Enoxaparin showed a significantly lower incidence of hematoma at the puncture site compared to UF (3.5% vs 8.8%).
  • One case of acute thrombosis during PCI occurred in the enoxaparin group, while one subacute thrombosis occurred in the UF group during follow-up.

Conclusions:

  • Enoxaparin demonstrates comparable efficacy and safety to UF for patients undergoing CAG/PCI.
  • Administering enoxaparin at least twice before CAG/PCI is safe and effective, allowing immediate sheath removal.
  • Enoxaparin can be used for percutaneous coronary intervention in acute coronary syndrome patients without additional UF if the last dose is within 8 hours.
Abstract

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