Volume measurement by CARTO compared with cardiac magnetic resonance

Area of Science:

• Cardiology
• Medical Imaging
• Electrophysiology

Background:

• The CARTO electrophysiological mapping system is validated for ventricular volume assessment in non-human models.
• Cardiac magnetic resonance (CMR) is the gold standard for non-invasive ventricular volume quantification.
• No direct comparison between CARTO and CMR for ventricular volumes in humans existed.

Purpose of the Study:

• To compare CARTO electrophysiological mapping system-derived ventricular volumes with CMR in heart failure patients.
• To assess the correlation and interchangeability of these two imaging modalities for volumetric analysis.

Main Methods:

• 34 heart failure patients (NYHA class III/IV) underwent both CARTO mapping and CMR for ventricular volume measurements.
• Left ventricular (LV) and right ventricular (RV) end-diastolic volumes (EDV) were measured using both techniques.
• Statistical analysis included correlation and Bland-Altman analysis to assess agreement.

Main Results:

• Mean LV end-diastolic volumes were comparable between CMR and CARTO (P = NS).
• CARTO system measured significantly larger RV end-diastolic volumes compared to CMR (P < 0.01).
• A good correlation was observed for both chambers, but Bland-Altman analysis indicated non-interchangeability; differences were influenced by mapping point density.

Conclusions:

• While CARTO and CMR show good correlation for LVEDV and RVEDV in heart failure patients, their clinical interchangeability is questionable.
• The number of acquired mapping points impacts measurement accuracy, suggesting potential limitations for CARTO in precise volumetric assessment.
• Further research may be needed to refine CARTO protocols for improved volumetric accuracy and interchangeability with CMR.