Related Experiment Video

Updated: Aug 9, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Biventricular vs. left univentricular pacing in heart failure: rationale, design, and endpoints of the B-LEFT HF

Christophe Leclercq1, Gerardo Ansalone, Fredrik Gadler

  • 1Department of Cardiology, Rennes University Hospital CHU Pontchaillou, 2, rue Henri Le Guilloux, Cedex 9, 35033 Rennes, France. christophe.leclercq@chu-rennes.fr

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|April 22, 2006
PubMed

Insights

Left ventricular (LV) pacing may be as effective as biventricular (BiV) pacing for heart failure patients. The B-LEFT HF trial compares the safety and efficacy of these cardiac resynchronization therapy (CRT) approaches.

Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Trials

Background:

  • Cardiac resynchronization therapy (CRT) benefits heart failure (HF) patients with systolic dysfunction and ventricular dyssynchrony.
  • Biventricular (BiV) pacing is the standard CRT method, addressing electrical and mechanical dyssynchrony.
  • Left ventricular (LV) only pacing shows promise as an alternative CRT strategy.

Purpose of the Study:

  • To compare the safety and effectiveness of LV only pacing versus BiV pacing in heart failure patients.
  • To evaluate LV pacing as a potentially simpler and less costly alternative to BiV pacing.
  • The B-LEFT HF trial aims to resolve critical questions regarding LV pacing in CRT.

Main Methods:

  • An international, prospective, randomized, double-blind, parallel-design clinical trial.
  • 172 heart failure patients will be randomized to either LV only or BiV pacing.
  • Efficacy endpoints assessed at 6 months include functional capacity, reverse remodeling, and clinical composite response.

Main Results:

  • Primary endpoints: changes in functional capacity and reverse remodeling.
  • Secondary endpoints: changes in heart failure clinical composite response.
  • Study results will determine the non-inferiority of LV pacing compared to BiV pacing.

Conclusions:

  • LV only pacing may offer similar benefits to BiV pacing with potential advantages in technical ease and cost.
  • The B-LEFT HF trial is designed to provide definitive evidence on the comparative safety and effectiveness of these CRT pacing strategies.
  • Findings will inform clinical practice regarding CRT in heart failure management.
Abstract

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