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Updated: Aug 9, 2026
03:38
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
Quantitative analysis for computed tomography findings of various diffuse lung diseases using volume histogram
Hiromitsu Sumikawa1, Takeshi Johkoh, Shuji Yamamoto
1Department of Diagnostic and Interventional Radiology, Osaka University Medical School, Osaka, Japan. h-sumikawa@radiol.med.osaka-u.ac.jp
Journal of Computer Assisted Tomography
|April 22, 2006
Summary
Volume histogram analysis quantitatively assesses interstitial pneumonia on CT scans. This method effectively evaluates diffuse lung diseases and treatment response, showing significant changes in variance and entropy values.
Area of Science:
- Radiology
- Pulmonary Medicine
- Medical Imaging Analysis
Background:
- Interstitial pneumonia encompasses a group of diffuse lung diseases with characteristic findings on computed tomography (CT).
- Quantitative analysis of CT findings can aid in disease characterization and treatment monitoring.
Purpose of the Study:
- To quantitatively analyze characteristic CT findings in interstitial pneumonia using the volume histogram method.
- To evaluate the effectiveness of volume histogram analysis in assessing disease course and treatment response.
Main Methods:
- Whole-lung volume histogram parameters, including contrast (CNT), variance (VAR), and entropy (EPY), were calculated.
- These parameters were compared between normal lungs and five distinct interstitial lung diseases.
- Thirteen cases of nonspecific interstitial pneumonia (NSIP) were analyzed before and after treatment.
Main Results:
- VAR and EPY values were significantly higher in interstitial pneumonia cases compared to normal lungs.
- In NSIP cases, post-treatment CNT values increased significantly, while VAR and EPY values decreased significantly.
- These findings indicate distinct quantitative CT patterns associated with different interstitial lung diseases and treatment effects.
Conclusions:
- Volume histogram analysis provides a quantitative method for evaluating diffuse lung diseases.
- This technique shows promise for assessing the effectiveness of treatments for interstitial pneumonia.
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