Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Na(+)-H+ exchanger subtypes: a predictive review.

J D Clark1, L E Limbird

  • 1Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232.

The American Journal of Physiology
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated estrous detection using multiple commercial precision dairy monitoring technologies in synchronized dairy cows.

Journal of dairy science·2019
Same author

The inflammasome as a target for pain therapy.

British journal of anaesthesia·2016
Same author

Stall cleanliness and stall temperature of two different freestall bases.

Journal of dairy science·2015
Same author

Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment.

The British journal of dermatology·2013
Same author

Influence of breed, milk production, season, and ambient temperature on dairy cow reticulorumen temperature.

Journal of dairy science·2013
Same author

Opiate-induced changes in brain adenosine levels and narcotic drug responses.

Neuroscience·2012
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

Research suggests that sodium-hydrogen (Na(+)-H(+)) exchangers may exist as distinct subtypes, rather than a single type. Understanding these potential subtypes is crucial for cell function and may aid in identifying new gene products.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Physiology

Background:

  • Proteins previously considered single entities are now recognized as heterogeneous, existing in distinct subtypes.
  • Subtyping is facilitated by pharmacological agents, functional assays, and molecular genetics.
  • Research is actively exploring the functional significance of protein subtypes within cellular contexts.

Purpose of the Study:

  • To review evidence supporting the existence of multiple sodium-hydrogen (Na(+)-H(+)) exchanger subtypes.
  • To predict distinguishing characteristics of these putative Na(+)-H(+) exchanger subtypes.
  • To correlate predicted gene products with previously identified Na(+)-H(+) exchangers.

Main Methods:

  • Review of existing scientific literature on protein heterogeneity and ion transporters.

Related Experiment Videos

  • Analysis of pharmacological, functional, and molecular biological data.
  • Prediction of characteristics for unconfirmed Na(+)-H(+) exchanger subtypes.

    • Main Results:

    • Evidence suggests that Na(+)-H(+) exchange activity may be mediated by different exchanger subtypes.
    • Specific subtypes have not yet been definitively identified.
    • Potential distinguishing characteristics for putative subtypes are proposed.

    Conclusions:

    • The existence of Na(+)-H(+) exchanger subtypes is plausible and supported by current evidence.
    • Further research is needed to definitively identify and characterize these subtypes.
    • Predicted characteristics may aid in linking cloned gene products to functional exchangers.