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Hereditary fructose intolerance and celiac disease: a novel genetic association

Carolina Ciacci1, Daniela Gennarelli, Gabriella Esposito

  • 1Dipartimento di Medicina Clinica e Sperimentale, Università di Napoli Federico II, Napoli, Italy.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|April 25, 2006
PubMed

Insights

Celiac disease (CD) may be linked to hereditary fructose intolerance (HFI). Researchers found a higher incidence of CD in HFI patients, suggesting a potential association between these gastrointestinal disorders.

Area of Science:

  • Gastroenterology
  • Genetics
  • Pediatrics

Background:

  • Celiac disease (CD) is linked to various genetic disorders.
  • Hereditary fructose intolerance (HFI) has not been previously associated with CD.

Purpose of the Study:

  • To investigate a potential association between celiac disease and hereditary fructose intolerance.
  • To determine if CD is more prevalent in HFI patients.

Main Methods:

  • Identified celiac disease in 4 female patients with hereditary fructose intolerance.
  • Analyzed a cohort of 38 Italian patients diagnosed with HFI.

Main Results:

  • Celiac disease was found in 4 out of 38 HFI patients (incidence >10%).
  • CD signs in pediatric HFI patients included hypertransaminasemia, failure to thrive, low weight, and short stature.
  • An adult HFI patient presented with protracted diarrhea despite a fructose-free diet.

Conclusions:

  • The study suggests a possible association between celiac disease and hereditary fructose intolerance.
  • This association is clinically significant for managing HFI patients with persistent gastrointestinal symptoms.
Abstract

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