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Keratoacanthoma centrifugum marginatum: response to topical 5-fluorouracil
Sayuri Yuge1, Deise Aparecida Santos Godoy, Maria Carolina Coelho de Melo
1Department of Dermatology, Instituto Lauro de Souza Lima, São Paulo, Brazil. sayuriyuge@zipmail.com.br
Journal of the American Academy of Dermatology
|April 25, 2006
Summary
This study reports a rare case of Keratoacanthoma centrifugum marginatum (KCM) treated successfully with topical 5-fluorouracil. This marks the third documented instance of KCM responding to this specific topical treatment.
Area of Science:
- Dermatology
- Oncology
Background:
- Keratoacanthoma centrifugum marginatum (KCM) is a rare keratoacanthoma variant.
- KCM exhibits distinctive peripheral growth and central healing patterns.
Observation:
- A patient with KCM was treated with topical 5% 5-fluorouracil.
- This represents the third reported case of KCM managed with this therapeutic approach.
Findings:
- Topical 5-fluorouracil demonstrated efficacy in treating KCM.
- The treatment aligns with previous limited case reports.
Implications:
- Topical 5-fluorouracil may be a viable treatment option for KCM.
- Further research is warranted to establish its role in KCM management.
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