Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genes of type 2 diabetes in beta cells.

Mirko Trajkovski1, Hassan Mziaut, Peter E Schwarz

  • 1Experimental Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.

Endocrinology and Metabolism Clinics of North America
|April 25, 2006
PubMed
Summary

This review explores type 2 diabetes susceptibility genes impacting pancreatic beta cells. It highlights calpain 10, identified via positional cloning, as a key genetic factor in diabetes development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Islet ultrastructure: past achievements and future directions.

Diabetologia·2026
Same author

Large-scale endoplasmic reticulum membrane solidification spatially organises proteins under thermal or metabolic stress.

bioRxiv : the preprint server for biology·2026
Same author

Explainable AI-based analysis of human pancreas sections identifies traits of type 2 diabetes.

Nature communications·2026
Same author

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.

Nature communications·2025
Same author

Prevention of type 2 diabetes through prediabetes remission without weight loss.

Nature medicine·2025
Same author

Subspecies of the human gut microbiota carry implicit information for in-depth microbiome research.

Cell host & microbe·2025

Area of Science:

  • Genetics
  • Metabolic Disorders
  • Endocrinology

Background:

  • Type 2 diabetes is a widespread polygenic metabolic disorder.
  • Pancreatic beta cells are crucial for insulin regulation and are often affected in diabetes.
  • Genetic factors play a significant role in the development of type 2 diabetes.

Purpose of the Study:

  • To provide an overview of type 2 diabetes susceptibility genes.
  • To focus on genes affecting pancreatic beta cells.
  • To emphasize the function and polymorphisms of these genes, particularly calpain 10.

Main Methods:

  • Review of existing literature on type 2 diabetes genetics.
  • Focus on positional cloning as a method for gene identification.
  • Analysis of gene function and relevant polymorphisms.

Related Experiment Videos

Main Results:

  • Identified several susceptibility genes for type 2 diabetes.
  • Highlighted the role of calpain 10 as a significant susceptibility gene.
  • Detailed the function and polymorphisms of calpain 10.

Conclusions:

  • Genetic factors significantly contribute to type 2 diabetes.
  • Calpain 10 is a key susceptibility gene for type 2 diabetes, identified through positional cloning.
  • Understanding these genes and polymorphisms is vital for future diabetes research and treatment.