The effects of mefenamic acid on hematocrit of the lizard, Uromastix hardwickii

Mefenamic acid is an analgesic, antipyretic and anti-inflammatory agent. In addition induces several hematological disturbances. Present study was conducted to determine the alterations in blood PCV of the lizard Uromastix hardwickii after the administration of 7.1 mg/ml; 10.5 mg/ml and 14.0 mg/ml mefenamic acid per individual per day for 12 days to 3 test groups. The mean values of PCV were 15.5+/-0.81%, 14.5+/-0.25% and 12.0+/-0.25% for 3 test groups respectively in comparison to 23.5+/-0.40% for control. Thus a significant dose dependant reduction in mean PCV per cent following the administration of mefenamic acid for 12 days indicates the extra vascular hemolysis due to destructive change in the red cell membrane through autoantibody mechanism.