Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Indeterminate colitis: a significant subgroup of pediatric IBD.

Ryan S Carvalho1, Vivian Abadom, Harrison P Dilworth

  • 1Johns Hopkins University School of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Baltimore, MD 21287, USA.

Inflammatory Bowel Diseases
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microplastics, nanoplastics and liver disease: an emerging health concern?

Nature reviews. Gastroenterology & hepatology·2026
Same author

Prevalence of liver disease and liver transplantation in pediatric ZZ alpha-1 antitrypsin deficiency: A systematic review and meta-analysis.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same author

The Student Voice Prize: ten years of learning from healthcare students.

Orphanet journal of rare diseases·2026
Same author

Increased Skeletal Muscle Fat in Patients With Haematological Cancer Is Associated With Reduced Cardiorespiratory Fitness.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Evaluation of a CZT-based photon-counting detector CT prototype for low-dose lung cancer screening using patient-specific lung phantoms.

medRxiv : the preprint server for health sciences·2026
Same author

Obese patient imaging: improved dose efficiency with photon-counting CT.

medRxiv : the preprint server for health sciences·2026
Same journal

Anorectal fibrosis in 3 murine models of chronic intestinal fibrosis: a comparative analysis.

Inflammatory bowel diseases·2026
Same journal

Patients with Crohn's disease achieving transmural healing experience superior long-term outcomes compared with those with endoscopic or radiologic healing alone.

Inflammatory bowel diseases·2026
Same journal

Higher body mass index is associated with lower drug concentrations in patients with inflammatory bowel disease treated with ustekinumab but not vedolizumab.

Inflammatory bowel diseases·2026
Same journal

Association of preoperative neoplasia and rectal cuff inflammation on initial pouchoscopy with subsequent neoplasia development in inflammatory bowel disease patients with an ileal pouch-anal anastomosis: a case-control study.

Inflammatory bowel diseases·2026
Same journal

Pediatric bowel-wall thickness cutoffs: calibration before implementation.

Inflammatory bowel diseases·2026
Same journal

Trained immunity: Breaking a dogma and a missing opportunity in IBD?

Inflammatory bowel diseases·2026
See all related articles

Indeterminate colitis (IC) is a distinct pediatric inflammatory bowel disease (IBD) subgroup. Children with IC present earlier and rapidly develop pancolitis, with many maintaining their IC diagnosis long-term.

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease (IBD) Research
  • Colitis Subtyping

Background:

  • Indeterminate colitis (IC) is an IBD classification challenge, lacking clear distinction from ulcerative colitis (UC) or Crohn's disease (CD).
  • Understanding IC's prevalence and characteristics in pediatric populations is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To determine the prevalence of IC in a pediatric IBD patient cohort.
  • To characterize the clinical presentation, natural history, and disease distribution of pediatric IC.
  • To identify potential differences in disease onset and progression compared to UC and CD.

Main Methods:

  • Retrospective analysis of pediatric IBD cases diagnosed between 1996-2001 at Johns Hopkins Children's IBD Center.

Related Experiment Videos

  • Review of demographic data, endoscopic, colonoscopic, histopathological, and radiological records.
  • Clinical follow-up to assess disease progression and diagnostic reclassification.

    • Main Results:

    • Indeterminate colitis (IC) accounted for 29.6% of pediatric IBD cases, a higher prevalence than in adults.
    • Pediatric IC patients were diagnosed at a younger mean age (9.5 years) compared to Crohn's disease (CD) (12.4 years).
    • Over 79% of IC patients presented with pancolitis; 33.7% were reclassified to CD or UC after follow-up, while 66.2% maintained their IC diagnosis.

    Conclusions:

    • Indeterminate colitis (IC) represents a significant and distinct subgroup within pediatric inflammatory bowel disease (IBD).
    • Early disease onset and rapid progression to pancolitis are characteristic of pediatric IC.
    • Further longitudinal studies are essential to elucidate the long-term clinical implications of this pediatric IBD classification.