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Updated: Aug 9, 2026

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Published on: February 13, 2026
[The solitary rectal ulcer syndrome]
Guillaume Meurette1, Nicolas Regenet, Eric Frampas
1Clinique Chirurgicale 2, CHU Hôtel-Dieu, Nantes. guillaume.meurette@chu-nantes.fr
Solitary rectal ulcer syndrome (SRUS) is a rare rectal disorder. Diagnosis involves symptoms, endoscopy, and histology, but effective long-term treatments remain challenging.
Area of Science:
- Gastroenterology
- Colorectal Surgery
Context:
- Solitary rectal ulcer syndrome (SRUS) is a rare, debilitating rectal disorder.
- Characterized by perianal pain, blood, and mucus discharge.
Purpose:
- To review the pathogenesis, diagnosis, and treatment of solitary rectal ulcer syndrome.
- To highlight diagnostic tools and therapeutic controversies.
Summary:
- Pathogenesis is uncertain, with rectal prolapse and straining as leading hypotheses.
- Diagnosis relies on clinical presentation, endoscopic findings (ulcerations, polyps), and histology.
- Manometry and defecography aid in identifying defecation disorders or rectal prolapse.
Impact:
- Current treatments, including conservative and surgical options, offer uncertain long-term outcomes.
- Further research is needed to clarify pathogenesis and improve therapeutic efficacy for SRUS.
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