Related Experiment Video
Updated: May 1, 2026

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration
Published on: June 26, 2015
Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
1Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China. Jason@bjmu.edu.cn
Abstract:
Endometrial cancer is the most common gynaecological cancer, and is associated with endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast cancer using selective oestrogen-receptor modulators (SERMs), particularly tamoxifen. Oestrogen and SERMs are thought to be involved in endometrial carcinogenesis through their effects on transcriptional regulation. Ultimately, oestrogen and SERMs affect the transduction of cellular signalling pathways that govern cell growth and proliferation, through downstream effectors such as PAX2 (paired box 2).
Related Concept Videos
Oogenesis
Mitogens and the Cell Cycle
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Disorders of the Female Reproductive System

