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Ankle Joint01:10

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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Related Experiment Video

Updated: Feb 16, 2026

Murine Bilateral Renal Lymphadenectomy
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Bilateral ankle edema with bilateral iritis.

Sunil Kumar1

  • 1Department of Ophthalmology, Mohammad Dossary Hospital, PO Box 335 Al Khobar 31952, Kingdom of Saudi Arabia. sunkaru79@hotmail.com

Clinical Rheumatology
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

Sarcoidosis can manifest with eye inflammation (iritis) and ankle swelling, even with normal chest X-rays. Early diagnosis through biopsy is crucial for managing this systemic inflammatory disease.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pathology

Background:

  • Sarcoidosis is a multisystem inflammatory disease of unknown etiology.
  • Ocular manifestations are common in sarcoidosis, but presentation can vary.
  • Systemic symptoms may not always be present or evident on initial examination.

Observation:

  • Two patients, a 42-year-old Indian female and a 30-year-old Somali female, presented with bilateral acute iritis.
  • One patient experienced bilateral ankle edema preceding iritis; the other developed edema after ocular symptoms.
  • Both patients had no prior significant ocular history and normal systemic clinical parameters.

Findings:

  • Lacrimal gland and conjunctival nodule biopsies confirmed sarcoidosis in both cases.
  • Diagnosis was established despite normal chest X-rays, highlighting potential for extrapulmonary sarcoidosis.
  • The varied timing of edema and iritis suggests different disease progression patterns.

Implications:

  • This case series underscores the importance of considering sarcoidosis in patients with unexplained iritis and edema, irrespective of chest imaging results.
  • Biopsy of accessible tissues like lacrimal glands or conjunctiva is vital for diagnosing sarcoidosis when other signs are absent.
  • Recognizing sarcoidosis in its diverse presentations is key for timely and effective patient management.