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The dopamine transporter proteome.

Gonzalo E Torres1

  • 1Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. gtorres@pitt.edu

Journal of Neurochemistry
|April 26, 2006
PubMed
Summary
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The dopamine transporter (DAT) regulates brain dopamine levels and is a target for drugs. New research explores DAT-interacting proteins, termed the DAT proteome, to understand transporter regulation.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Dopamine transporter (DAT) regulates dopamine homeostasis and neurotransmission.
  • DAT is the primary target for psychostimulants like cocaine and amphetamines.
  • DAT is also a target for medications treating ADHD and depression.

Purpose of the Study:

  • To investigate the cellular and molecular mechanisms regulating DAT function.
  • To identify and characterize proteins that interact with DAT.
  • To understand the functional implications of these DAT protein-protein interactions.

Main Methods:

  • Systematic search for DAT protein-protein interactions.
  • Characterization of identified DAT-interacting proteins.
  • Review of existing literature on DAT regulation.

Related Experiment Videos

Main Results:

  • Numerous proteins interacting with DAT have been identified.
  • These interactions may influence DAT assembly, targeting, trafficking, and function.
  • The concept of the 'DAT proteome' is proposed to explain regulatory mechanisms.

Conclusions:

  • DAT protein-protein interactions represent a novel regulatory mechanism for DAT function.
  • Understanding the DAT proteome can elucidate transporter regulation.
  • This knowledge may lead to new therapeutic strategies for neurological and psychiatric disorders.