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Updated: Aug 9, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Bisoprolol improves echocardiographic parameters of left ventricular diastolic function in patients with systemic

T Fikret Ilgenli1, Fethi Kilicaslan, Ata Kirilmaz

  • 1Golcuk Army Hospital, Department of Cardiology, Golcuk, Kocaeli, Turkey. fikretilgenli@yahoo.com

Cardiology
|April 26, 2006
PubMed

Insights

Bisoprolol treatment improved left ventricular (LV) diastolic function in hypertensive patients. Echocardiography showed better diastolic parameters after three months, indicating bisoprolol

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension frequently causes left ventricular (LV) diastolic dysfunction (LVD).
  • Bisoprolol is known to reduce blood pressure and offer cardiac benefits in hypertensive individuals.
  • The specific impact of bisoprolol on LV diastolic function requires further detailed investigation.

Purpose of the Study:

  • To investigate the effects of bisoprolol on left ventricular diastolic function in hypertensive patients.

Main Methods:

  • A study involving 25 patients was conducted.
  • Echocardiography was used to measure key diastolic parameters: Peak E and A waves, E/A ratio, isovolumetric relaxation time, and E wave deceleration time.
  • Statistical analysis was performed on the collected data.

Main Results:

  • Doppler echocardiography revealed significant improvements in LV diastolic function post-bisoprolol treatment.
  • Specific echocardiographic parameters associated with diastolic function showed enhancement.

Conclusions:

  • Bisoprolol treatment demonstrates a positive effect on LV diastolic function.
  • A three-month course of bisoprolol improves echocardiographic indicators of diastolic function in hypertensive patients.

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