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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Enhancement in dissolution pattern of piribedil by molecular encapsulation with beta-cyclodextrin
Muzeyyen Demirel1, G Buyukkoroglu, B S Kalava
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey. mdemirel@anadolu.edu.tr
Summary
Molecular encapsulation of piribedil using beta-cyclodextrin (beta-CD) significantly enhanced drug dissolution. Spray-drying successfully prepared these complexes, improving piribedil
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Piribedil is a medication used for treating Parkinson's disease.
- Improving the dissolution rate of poorly soluble drugs like piribedil is crucial for enhancing bioavailability.
Purpose of the Study:
- To enhance the dissolution behavior of piribedil through molecular encapsulation.
- To prepare and characterize solid binary systems of piribedil and beta-cyclodextrin (beta-CD).
Main Methods:
- Solid binary systems were prepared using physical mixing, co-grinding, and spray-drying.
- Characterization of the binary systems involved differential scanning calorimetry, X-ray diffractometry, and particle size analysis.
Main Results:
- Spray-drying was identified as an effective method for preparing piribedil-beta-CD complexes.
- The dissolution of piribedil was significantly improved when complexed with beta-CD using the spray-drying technique.
Conclusions:
- Molecular encapsulation with beta-CD, particularly via spray-drying, is a viable strategy to enhance piribedil dissolution.
- This approach holds potential for improving the therapeutic efficacy of piribedil.
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