Jove
Visualize
Contact Us

Related Experiment Videos

Heterovalent selectivity and the combinatorial advantage.

Samuel J Reyes1, Kevin Burgess

  • 1Department of Chemistry, Box 30012, Texas A & M University, College Station, TX 77842-3012, USA. burgess@tamu.edu

Chemical Society Reviews
|April 26, 2006
PubMed
Summary

This study reviews methods for selectively synthesizing heterobivalent compounds from monovalent precursors. Achieving selectivity is crucial for avoiding statistical mixtures and unlocking the potential of bivalent molecules.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FOXO1 in cancer: context-dependent roles, microRNA regulation, and therapeutic opportunities.

Discover oncology·2026
Same author

Novel Neurotrophin-3 peptidomimetic synthetic neurotrophin promotes neurological recovery after spinal cord injury.

Experimental neurology·2026
Same author

PROTACs for Collateral Degradation: Is It Time to Back Up the Bus?

ACS medicinal chemistry letters·2026
Same author

Forces behind N- and C-capping of peptidic helices.

Chemical communications (Cambridge, England)·2026
Same author

Cancer immunotherapeutic targeting tropomyosin receptor kinase C (TrkC) through its conjugate and cyclophosphamide.

Immunopharmacology and immunotoxicology·2025
Same author

Small-Molecule Trk Agonists: Where Do We Go from Here?

Journal of medicinal chemistry·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Chemistry
  • Organic Synthesis
  • Combinatorial Chemistry

Background:

  • Libraries of monovalent compounds can be combined to create libraries of bivalent compounds.
  • Rapid production of diverse bivalent compounds offers a combinatorial advantage.
  • Selective formation of heterobivalent products is necessary to avoid statistical mixtures.

Purpose of the Study:

  • To review methods for the selective synthesis of heterobivalent compounds.
  • To highlight techniques that yield heterobivalent compounds almost exclusively.
  • To underscore the growing importance of selective synthesis methods for bivalent compounds.

Main Methods:

  • The review focuses on established and emerging synthetic strategies for selective heterobivalent compound formation.

Related Experiment Videos

  • Discussion includes methods that bypass the need for product purification.
  • Emphasis is placed on achieving high selectivity in the formation of mixed bivalent structures.

    • Main Results:

    • Several methods exist that enable the highly selective synthesis of heterobivalent compounds.
    • These selective methods are essential for avoiding the formation of statistical product mixtures.
    • The development of such selective synthetic routes is critical for advancing the applications of bivalent compounds.

    Conclusions:

    • Selective synthesis is key to efficiently producing heterobivalent compounds.
    • Despite limited methods, their importance is increasing with emerging applications.
    • These techniques are vital for accessing pure heterobivalent compounds for further research and development.