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m-Chlorophenylpiperazine as a probe of serotonin function.
Biological Psychiatry
|December 1, 1991
Summary
m-Chlorophenylpiperazine (mCPP) is a reliable serotonin (5HT) agonist used to assess 5HT receptor sensitivity. It induces predictable physiological and behavioral changes in animals and humans, aiding psychiatric research.
Area of Science:
- Psychopharmacology
- Neuroscience
- Psychiatry
Background:
- m-Chlorophenylpiperazine (mCPP) is widely utilized as a probe for serotonin (5HT) function.
- Understanding mCPP's properties is crucial for its application in psychiatric research.
Purpose of the Study:
- To review the in vitro and in vivo properties of mCPP.
- To evaluate mCPP as a tool for assessing 5HT receptor sensitivity.
Main Methods:
- Review of existing literature on mCPP's effects in animals, humans, and psychiatric patients.
- Analysis of mCPP's in vitro and in vivo pharmacological and physiological actions.
Main Results:
- mCPP acts as a safe and reliable direct 5HT agonist.
- It causes dose-dependent elevations in ACTH, cortisol, prolactin, and body temperature.
- mCPP elicits varied behavioral effects, likely mediated by 5HT receptors.
Conclusions:
- mCPP is a valuable tool for evaluating 5HT receptor sensitivity.
- Its consistent effects make it important for psychiatric research, pending more selective agonists.