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Linear lichen planus and hepatitis C.
María Victoria Guiote Domínguez1, Anna Vilanova Mateu, Ricardo Vieira
1Department of Dermatology, San Cecilio Hospital, Granada, Spain. viviguiote@yahoo.es
Dermatology Online Journal
|April 28, 2006
Summary
A man with hepatitis C developed linear lichen planus during interferon therapy. The skin condition resolved with topical tacrolimus, suggesting a link between hepatitis C, interferon treatment, and this rare skin disorder.
Area of Science:
- Dermatology
- Hepatology
- Immunology
Background:
- Hepatitis C is a viral infection affecting the liver.
- Interferon-alpha therapy is a common treatment for hepatitis C.
- Linear lichen planus is a rare dermatological condition characterized by papules in a linear arrangement.
Observation:
- A 23-year-old male patient with hepatitis C presented with brownish, dome-shaped papules on his chest in a distinct linear pattern.
- Clinical and pathological examinations confirmed the diagnosis of linear lichen planus.
- The skin lesions emerged during interferon-alpha treatment for his hepatitis C infection.
Findings:
- The patient's linear lichen planus lesions resolved completely after topical application of tacrolimus ointment.
- This case represents one of the few documented instances of linear lichen planus associated with hepatitis C.
- The temporal relationship suggests a potential link between interferon-alpha therapy and the development of linear lichen planus in hepatitis C patients.
Implications:
- This case highlights a potential adverse reaction to interferon-alpha therapy in hepatitis C patients, manifesting as linear lichen planus.
- Further research is warranted to elucidate the immunopathogenesis underlying the association between hepatitis C, interferon therapy, and linear lichen planus.
- The successful treatment with topical tacrolimus provides a therapeutic option for this rare condition.