Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treatment-refractory schizophrenia.

Peter F Buckley1, Nitin Shendarkar

  • 1Department of Psychiatry, Medical College of Georgia, Augusta, Georgia 30912, USA. pbuckley@mail.mcg.edu

Current Opinion in Psychiatry
|April 28, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological insights into schizophrenia from ancestrally diverse populations.

Nature·2026
Same author

Latent class analysis of symptoms across schizophrenia, schizoaffective disorder, and bipolar I disorder.

medRxiv : the preprint server for health sciences·2025
Same author

Insomnia and cardiovascular disease risk in schizophrenia.

Schizophrenia research·2024
Same author

Longitudinal study of insomnia, suicidal ideation, and psychopathology in schizophrenia.

Schizophrenia research·2024
Same author

Longitudinal study of inflammation and relapse in schizophrenia.

Schizophrenia research·2023
Same author

The Future of Endowed Chairs in Academic Medicine.

Academic medicine : journal of the Association of American Medical Colleges·2022
Same journal

Neuroimaging in older-age bipolar disorder.

Current opinion in psychiatry·2026
Same journal

Repetitive transcranial magnetic stimulation treatment for obsessive-compulsive disorder.

Current opinion in psychiatry·2026
Same journal

Pharmacological maintenance treatment in older age bipolar disorder.

Current opinion in psychiatry·2026
Same journal

Harmful behaviours and suicide in later life bipolar disorder.

Current opinion in psychiatry·2026
Same journal

Urbanization, wildfire exposure, and youth mental health: a narrative review.

Current opinion in psychiatry·2026
Same journal

Bipolar disorder and the risk of developing dementia - a systematic review and meta-analysis.

Current opinion in psychiatry·2026
See all related articles

This review highlights advances in treating treatment-refractory schizophrenia with second-generation antipsychotics. Emerging data also address medication side effects and pharmacogenetics in this patient group.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Schizophrenia treatment remains challenging, particularly for treatment-refractory cases.
  • Understanding the nuances of second-generation antipsychotics (SGAs) is crucial.

Purpose of the Study:

  • To critically review current literature on treatment-refractory schizophrenia.
  • To emphasize emergent themes and key findings in managing this condition.

Main Methods:

  • Literature review of recent studies on treatment-refractory schizophrenia.
  • Analysis of emergent themes and key findings regarding SGA efficacy and safety.

Main Results:

  • New data illuminate the impact of SGAs on treatment-refractory schizophrenia, including cognition, suicidality, and violence.

Related Experiment Videos

  • Pharmacogenetics research aims to predict patient response and side-effect risks.
  • Polypharmacy is a prevalent but poorly understood treatment strategy.

    • Conclusions:

    • Therapeutic strategies for treatment-refractory schizophrenia are advancing with SGAs.
    • There is increased awareness of SGA adverse effect profiles, especially in severely ill patients.
    • Risk-benefit assessments are critical when using SGAs in this population.