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Heparin-induced thrombocytopenia following pancreatectomy and islet auto-transplantation

Cristiana Rastellini1, Melissa L Brown, Luca Cicalese

  • 1Department of Surgery, Division of Transplantation, University of Massachusetts Medical Center, Worcester, 01605, USA. cristiana.rastellini@umassmed.edu

Clinical Transplantation
|April 28, 2006
PubMed

We report the case of a female with chronic pancreatitis who underwent multiple surgical procedures leading to total resection of the pancreas with successful islet auto-transplantation. Postoperatively, she developed heparin-induced thrombocytopenia. Heparinization prior to islet infusion is currently recommended to prevent portal vein thrombosis. Antibodies against heparin are not standard pre-operative testing for islet transplantation. Timely screening for heparin-dependent anti-platelet antibody should be kept in consideration for elective surgical cases (especially following previous surgeries) including pancreatic islet allo- and auto-transplantation.

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