Related Experiment Video
Updated: Aug 9, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
An antimalarial tetrapeptide from the entomopathogenic fungus Hirsutella sp. BCC 1528
Jiraporn Thongtan1, Janya Saenboonrueng, Pranee Rachtawee
1National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, 113 Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
Abstract:
Hirsutellic acid A (1), a new linear tetrapeptide possessing an anthranilic acid residue at the C-terminus, was isolated from a fermentation broth of the entomopathogenic fungus Hirsutella sp. BCC 1528. The structure of this compound was elucidated by NMR and MS analyses, and its absolute configuration was deduced by HPLC analysis of the acid hydrolysate using a chiral column. Hirsutellic acid A exhibits activity against the malarial parasite Plasmodium falciparum K1 with an IC(50) value of 8.0 microM, while it was noncytotoxic to Vero cells at a concentration of 95 microM.
More Related Videos
06:58Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer
Published on: September 29, 2023
09:42Isolation and Selection of Entomopathogenic Fungi from Soil Samples and Evaluation of Fungal Virulence against Insect Pests
Published on: September 28, 2021
Related Concept Videos
Anthelminthic Agents
Malaria
Antiprotozoal Agents
Antifungal Agents