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Changes of ATPase activities in erythrocytes of rats with hypothalamic obesity
H Remke1, A Wilsdorf, A Rehorek
1University of Leipzig, Institute of Pathological Biochemistry, Germany.
Experimental Pathology
|January 1, 1991
Abstract:
Na,K- and Ca,Mg-ATPase activities in the membrane of red blood cells (RBC) were determined in glutamate treated obese rats (GOR). Both activities are related oppositely. In the obese rats the Na,K-ATPase is higher but the efficiency in maintenance of Na/K-ion concentration gradients is diminished. Ca,Mg-ATPase is decreased in GOR. Under the hypermetabolic condition of cold adaption the Na,K-ATPase activity decreases and the Ca,Mg-ATPase activity rises in both animal groups. The Na,K-ATPase activity in RBC-membranes is positively related to fat accumulation and age.