[The cardiovascular reactions during audiogenic seizures in rats genetically predisposed to epilepsy]

Changes in arterial pressure (AP) and venous tone were studied in Krushinskiĭ-Molodkina (KM) rats genetically predisposed to audiogenic seizure, during the audio stress and 20 min after it. The venous tone was estimated by the mean circulatory filling pressure (MCFP) during a short arrest of circulation by inflating a balloon in the right atrium. It was shown that, during seizure, AP raised from 104 to 156 mm Hg on the average, while MCFP decreased from 8.9 to 7.4 mm Hg. Ganglion blockade with hexamethonium did not prevent the development of pressor reaction during seizure. The intensity of subdural and subarachnoidal hemorrhagic correlates with the raise of AP during seizure. The hemorrhagic area spread over 75 mm2 during AP greater than 200 m Hg, while in lower increment it was only 2.56 mm2. The KM rats can be used in experimental modelling of brain circulation disorders caused by acute increase in AP.