[The effect of GABA-ergic preparations on the function of the hypothalamo-hypophyseal-adrenal system in patients with Itsenko-Cushing disease]

The effect of aminalon, baclofen and valproic acid on the levels of ACTH and cortisol was investigated in 58 patients with Itsenko-Cushing disease. The effect of GABAergic drugs showed correlation with the basal level of blood GABA: with aminalon and valproic acid the effect was observed only in patients with a low level of GABA, with baclofen--in patients with a high level of GABA there was found a decrease in the level of ACTH, associated with a high level of cortisol.