Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Obsessive-compulsive spectrum disorders: a multidimensional approach.

Dan J Stein1, Christine Lochner

  • 1Department of Psychiatry, University of Cape Town, Cape Town, South Africa. dan.stein@curie.uct.ac.za

The Psychiatric Clinics of North America
|May 3, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

The Development of the Paraphilic Disorders Short Screen (PDSS) and Its Examination in Diverse Populations: A Large, Multi-Nation Study.

Sexual abuse : a journal of research and treatment·2026
Same author

Resting-state functional connectivity alterations in obsessive-compulsive disorder: relationships between connectivity and clinical profiles in the Global OCD study.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Early adversity links more to transdiagnostic than obsessive-compulsive disorder (OCD)-specific features: Findings from a large multinational study.

Comprehensive psychiatry·2026
Same author

Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Body-Focused Repetitive Behavior Disorders: From Competing Paradigms Toward Iterative Integration.

Annual review of clinical psychology·2026
Same journal

Digital Mental Health: Progress but not Perfection.

The Psychiatric clinics of North America·2026
Same journal

Advances in Mental Health Technology.

The Psychiatric clinics of North America·2026
Same journal

The Future of Digital Mental Health: A Literature Review.

The Psychiatric clinics of North America·2026
Same journal

Assessment and Treatment of Posttraumatic Stress Disorder via Digital Mental Health Technology.

The Psychiatric clinics of North America·2026
Same journal

Treatment of Obsessive-Compulsive Disorder via Mental Health Technology.

The Psychiatric clinics of North America·2026
Same journal

Digital Mental Health Treatments for Depression.

The Psychiatric clinics of North America·2026
See all related articles

Obsessive-compulsive spectrum disorders may share underlying psychobiologic processes but require distinct treatments due to varied disruptions. Further research into cortico-striatal circuitry and serotonin is crucial for refining these concepts.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Obsessive-compulsive disorder (OCD) and related conditions may stem from shared psychobiologic mechanisms.
  • Conceptualizing these disorders as a spectrum suggests potential for common therapeutic targets.
  • However, distinct disruptions within shared pathways might necessitate tailored treatment strategies.

Purpose of the Study:

  • To explore the potential for distinct treatments within the obsessive-compulsive spectrum.
  • To examine the role of psychobiologic processes, specifically cortico-striatal circuitry and serotonergic neurotransmission, in OCD and related disorders.
  • To highlight the need for further research in cognitive-affective neuroscience for precise diagnostic and therapeutic approaches.

Main Methods:

Related Experiment Videos

  • Review of existing literature on obsessive-compulsive spectrum disorders.
  • Analysis of neurobiological underpinnings, including cortico-striatal pathways and serotonin.
  • Examination of empirical data supporting shared and distinct features.

    • Main Results:

    • Cortico-striatal circuitry is implicated in OCD and several other obsessive-compulsive spectrum disorders.
    • A selective response to serotonin-reuptake inhibitors is observed across a range of these disorders.
    • Despite shared pathways, the specific disruption may differ, suggesting varied treatment needs.

    Conclusions:

    • Obsessive-compulsive spectrum disorders may require individualized treatment approaches despite shared neurobiological features.
    • Understanding the precise role of cortico-striatal circuits and serotonin in different spectrum disorders is essential.
    • Continued research in cognitive-affective neuroscience will refine our understanding and treatment of these conditions.