Related Experiment Video
Updated: May 1, 2026

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
Published on: January 20, 2012
Hypochondriasis: conceptualization, treatment, and relationship to obsessive-compulsive disorder
Jonathan S Abramowitz1, Autumn E Braddock
1OCD/Anxiety Disorders Program, Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. abramowitz.jonathan@mayo.edu
Insights
Health anxiety (HC) is now recognized as a primary diagnosis, often stemming from an anxiety disorder focused on fears of serious illness. Cognitive-behavioral and pharmacologic treatments show promise, though patient reluctance to accept psychological aspects remains a challenge.
Area of Science:
- Psychiatry
- Psychology
Background:
- Health anxiety (HC) was historically viewed as secondary to other mental disorders.
- HC is now understood as a primary diagnosis, characterized by intense fear of serious physical illness.
Purpose of the Study:
- To explore the conceptualization and treatment of health anxiety.
- To highlight the role of maladaptive beliefs and behaviors in maintaining HC.
- To discuss challenges and strategies in treating HC.
Main Methods:
- The study reviews existing evidence on the conceptualization of HC.
- It examines the role of cognitive-behavioral and pharmacologic treatments.
- It discusses patient-provider interactions and therapeutic alliance.
Main Results:
- Health anxiety involves erroneous beliefs and maladaptive behaviors that perpetuate threat perception.
- Cognitive-behavioral and pharmacologic interventions are effective in reducing HC symptoms.
- Patient reluctance to acknowledge the psychological nature of HC is a significant treatment barrier.
Conclusions:
- Effective treatment of HC relies on addressing maladaptive beliefs and behaviors.
- Building trust and providing logical explanations for psychological services are crucial for patient engagement.
- Understanding HC as an anxiety disorder is key to successful therapeutic outcomes.
Abstract:
Once considered exclusively as a problem secondary to other mental dis-orders (ie, mood disorders), HC is now known to occur quite often as a pri-mary diagnosis. A frequent drain on medical resources, patients who have HC can be viewed as suffering essentially from an anxiety disorder in which intense fear is focused on the possibility that they might be seriously physically ill or that such illness is imminent. The processes that contribute to the development and maintenance of such health anxiety consist largely of beliefs, assumptions, and behavioral responses that, although internally consistent with the perception of health-related threat, are erroneous and highly maladaptive in that they prevent the correction of erroneous perceptions of threat. There is growing evidence that this conceptualization leads to effective reduction in HC symptoms through cognitive-behavioral and pharmacologic treatments. By far the main obstacle to successful treatment of HC is the patient's reluctance to view the problem as anything other than physical. The authors have found, however, that patients appreciate their care providers showing a genuine understanding of their concerns and taking the time to offer a logical, coherent explanation and rationale for the need for psychological and psychiatric services.
More Related Videos
Related Concept Videos
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Generalized Anxiety Disorder
Obsessive-Compulsive Disorder
Bulimia Nervosa
Personality Disorders: Dependent and Obsessive-Compulsive
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...

