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Published on: July 17, 2020
Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense
Surat Laphookhieo1, John Keith Syers, Rattana Kiattansakul
1School of Science, Mae Fah Luang University, Thasud, Muang, Chiang Rai 57100, Thailand. surat@mfu.ac.th
Abstract:
A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), alpha-mangostin (5), beta-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4-7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC(50) values ranging from 0.65 to 5.2 microg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC(50) values of 3.2, 4.9, 7.2 and 2.6 microg/ml, respectively.
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