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Updated: Aug 8, 2026
06:08
Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
[Nasal allergy and asthma: one or two diseases?]
Pascal Demoly1, Patricia Rullier-Meyer, Philippe Godard
1Maladies Respiratoires, INSERM U454, IFR3, Hôpital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier cedex 05.
Bulletin De L'Academie Nationale De Medecine
|May 4, 2006
Summary
Rhinitis and asthma share common inflammatory pathways and cells. While nasal inflammation mirrors bronchial inflammation, asthma exhibits distinct airway remodeling not seen in rhinitis.
Area of Science:
- Immunology
- Pulmonology
- Allergology
Context:
- Epidemiological data reveal a strong association between rhinitis and asthma.
- Four out of five asthmatics have rhinitis; one out of four rhinitic individuals develop asthma.
- Shared inflammatory cells and molecular mechanisms underpin both conditions' pathophysiology.
Purpose:
- To explore the link between rhinitis and asthma.
- To compare the inflammatory and remodeling features of rhinitis and asthma.
- To understand the basis for ARIA guidelines.
Summary:
- Cellular and molecular biology confirm shared inflammatory pathways in rhinitis and asthma.
- Histological analysis indicates similar nasal and bronchial inflammation but distinct airway remodeling in asthma.
- Differences in embryologic origin may explain the lack of remodeling in rhinitis.
Impact:
- Understanding the shared pathophysiology supports the ARIA guidelines.
- Clinical guidelines recommend screening asthmatics for rhinitis and vice versa.
- This highlights the importance of managing rhinitis in asthma patients and vice versa.
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