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Natural products and anti-inflammatory activity
Gaofeng Yuan1, Mark L Wahlqvist, Guoqing He
1Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou, Zhejiang, China 310029.
Asia Pacific Journal of Clinical Nutrition
|May 5, 2006
Summary
This review summarizes potent natural products with anti-inflammatory activity, such as curcumin and Boswellia serrata. These natural compounds show significant potential for preventing and treating inflammatory conditions.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Inflammation Research
Background:
- Inflammatory conditions represent a significant global health burden.
- Natural products have historically been a source of therapeutic agents.
- There is a growing interest in identifying natural compounds for managing inflammation.
Purpose of the Study:
- To review commonly available natural products with demonstrated anti-inflammatory activity.
- To highlight potent natural compounds for potential therapeutic applications.
- To consolidate information from existing scientific literature on natural anti-inflammatories.
Main Methods:
- Comprehensive literature search of MEDLINE, Current Contents, and scientific journals.
- Inclusion of 92 publications detailing natural products and their anti-inflammatory effects.
- Selection of commonly available and potent natural products for summary.
Main Results:
- Curcumin, parthenolide, cucurbitacins, 1,8-cineole, pseudopterosins, lyprinol, bromelain, flavonoids, saponins, marine sponge products, and Boswellia serrata gum resin exhibit anti-inflammatory properties.
- These natural products play a crucial role in the prevention and treatment of inflammatory diseases.
- The reviewed compounds represent a diverse range of botanical and marine sources.
Conclusions:
- Natural products offer a promising avenue for the management of inflammatory conditions.
- Further research is warranted to elucidate mechanisms of action, metabolism, and safety profiles.
- Investigating potential interactions of these natural products with drugs and food is essential for clinical application.
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