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Related Experiment Videos

Down's syndrome and early cataract.

B Haargaard1, H C Fledelius

  • 1Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen, Denmark. bgd@ssi.dk

The British Journal of Ophthalmology
|May 5, 2006
PubMed
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Early cataract occurs in 1.4% of children with Down syndrome. Cataracts requiring surgery in childhood are rare, with many bilateral cases detected neonatally.

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Down syndrome is associated with various health issues, including ocular abnormalities.
  • Early detection and management of cataracts are crucial for visual development.

Purpose of the Study:

  • To determine the incidence of early-onset cataracts in pediatric patients with Down syndrome.
  • To describe the clinical features and management of these cases.

Main Methods:

  • Retrospective cohort study of Danish children (0-17 years) diagnosed with cataract between 1977-2001.
  • Analysis of medical records for 1027 cataract cases, identifying those with Down syndrome.

Main Results:

  • 2.8% (29/1027) of non-traumatic cataract cases were in children with Down syndrome.

Related Experiment Videos

  • The occurrence of early cataract in Down syndrome was 1.4%, with 27 cases of bilateral and 2 of unilateral cataract.
  • Half of the affected children (14/29) required cataract surgery, with early intervention in neonatal cases.

    • Conclusions:

    • Early cataract affects 1.4% of children with Down syndrome, with surgical intervention needed less frequently.
    • Bilateral cataracts were common, with a significant proportion diagnosed at birth and requiring early surgical management.