Related Experiment Video
Updated: Aug 8, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Uncontrollable prurigo nodularis effectively treated by roxithromycin and tranilast
Yasuhiro Horiuchi1, Sangjae Bae, Ichiro Katayama
1Department of Dermatology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan. ngu-yashoriu@r7.dion.ne.jp
Journal of Drugs in Dermatology : JDD
|May 6, 2006
Summary
Roxithromycin and tranilast combination therapy offers a new effective treatment for difficult prurigo nodularis (PN). This combination demonstrated significant regression of PN in patients unresponsive to conventional treatments.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Prurigo nodularis (PN) presents a therapeutic challenge, often resistant to standard treatments like potent corticosteroids.
- Existing therapies for PN have limitations, necessitating novel and effective treatment strategies.
Observation:
- This study investigated the efficacy of a combination therapy for intractable prurigo nodularis.
- Three cases of severe, treatment-resistant PN were analyzed.
Findings:
- Patients received a daily regimen of 300 mg roxithromycin and 200 mg tranilast.
- Complete or significant regression of prurigo nodularis lesions was observed within 4 to 6 months of combined treatment.
Implications:
- The combination of roxithromycin and tranilast shows promise as an effective treatment for refractory prurigo nodularis.
- This therapeutic approach may offer a valuable option for patients with severe, uncontrollable PN.
Related Concept Videos
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...