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Updated: May 29, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Epidermal growth factor receptor (EGFR) inhibitor associated skin eruption
Elizabeth V Seiverling1, Emmy M Fernanadez, David Adams
1Penn State College of Medicine, Hershey, PA 17033, USA.
Abstract:
EGFR Inhibitors are used to treat Non-Small-Cell Lung Cancer (NSCLC) and colorectal cancer (CRC). A common side effect of EGFR Inhibitors is a follicular/pustular skin eruption. We report a case of gefitinib (Iressa) associated skin eruption. The treatment regimen consisted of triamcinolone 0.1% cream twice daily, clindamycin 1% lotion twice daily and sodium sulfacetamide lotion twice daily. The clinical presentation, etiology, and management options of EGFR Inhibitor associated skin eruptions are discussed.
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