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Retinoids and their targets in vertebrate development.

C W Ragsdale1, J P Brockes

  • 1Ludwig Institute for Cancer Research, Middlesex Hospital, London, UK.

Current Opinion in Cell Biology
|December 11, 1991
PubMed
Summary

Retinoic acid

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Area of Science:

  • Developmental biology
  • Teratology
  • Molecular biology

Background:

  • Retinoic acid's role in limb development is under investigation.
  • Retinoids are involved in development, but their natural role in morphogenesis is unclear.
  • Understanding retinoid signaling may illuminate vertebrate pattern formation.

Purpose of the Study:

  • To investigate the teratogenic effects of retinoic acid.
  • To explore the mechanisms of vertebrate patterning.
  • To gain insight into the role of retinoids in morphogenesis.

Main Methods:

  • Analysis of retinoic acid teratology.
  • Study of retinoid nuclear receptors.
  • Investigation of cytoplasmic binding proteins.

Main Results:

  • Retinoic acid treatment prompts renewed investigation into limb morphogenesis.
  • Retinoids are deployed throughout development.
  • The natural role of retinoids in morphogenesis remains obscure.

Conclusions:

  • Studying retinoic acid receptors offers molecular insights into gene regulation.
  • This research may clarify vertebrate pattern formation mechanisms.
  • Further research is needed to fully understand retinoid functions in development.

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